International Circulation:  Finally， I know that there are side effects with amlodipine mono therapies so how significant is it? If there is a real improvement when we have the combination together with amlodipine?

国际循环：最后，我知道氨氯地平单一疗法有一定的不良反应，这到底有多大意义？与氨氯地平联合是否真的有所改善？

Dahlof:  I mean the improvement is not only with the figures， the improvement is also that you have less side effects and I think that it one advantage that many forget.  Amlodipine has this advantage of ankle edema when you give it together of a blocker of renin angiotensin system you can half or even two thirds the number of patients who have problems with ankle edema.  So I think it is a real advantage that you have more efficacious medication that is based on a very good mechanistic complimentary action of the two drugs in addition to being better tolerated than mono therapy can be especially mono therapy of calcium channel blocker.  

 Dahlof：我说的改善不单指临床数据，同时可以减少不良反应，这也是常被忽略的。氨氯地平与肾素血管紧张素拮抗剂联用，可缓和1/2至2/3患者的踝部水肿。这是基于两种药物机制的有益互补，获得比单一疗法尤其是钙通道阻断剂单一疗法更好的耐受性。

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